Testosterone Supplementation Therapy for Older Men: Potential Benefits and Risks

doi:10.1034/j.1601-5215.2002.51018.x

Paper

Testosterone Supplementation Therapy for Older Men: Potential Benefits and Risks

Published Jan 1, 2003 · D. Gruenewald, A. Matsumoto

Journal of the American Geriatrics Society

Q1 SJR score

273

Citations

3

Influential Citations

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Abstract

Serum testosterone levels decline gradually and progressively with aging in men. Many manifestations associated with aging in men, including muscle atrophy and weakness, osteoporosis, reduced sexual functioning, and increased fat mass, are similar to changes associated with testosterone deficiency in young men. These similarities suggest that testosterone supplementation may prevent or reverse the effects of aging. A MEDLINE search was performed to identify studies of testosterone supplementation therapy in older men. A structured, qualitative review was performed of placebo‐controlled trials that included men aged 60 and older and evaluated one or more physical, cognitive, affective, functional, or quality‐of‐life outcomes. Studies focusing on patients with severe systemic diseases and hormone deficiencies related to specific diseases were excluded.

Systematic Review

Highly Cited

Study Snapshot

Testosterone supplementation may prevent or reverse the effects of aging in men, potentially improving physical, cognitive, affective, functional, and quality-of-life outcomes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Testosterone Supplementation Therapy for Older Men: Potential Benefits and Risks

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References

Preoperative Supraphysiological Testosterone in Older Men Undergoing Knee Replacement Surgery

Preoperative supraphysiological testosterone therapy improves functional recovery and reduces hospital stay in older men undergoing knee replacement surgery.

Effects of transdermal testosterone on lipids and vascular reactivity in older men with low bioavailable testosterone levels.

Transdermal testosterone decreased HDL(2) cholesterol but did not affect vascular reactivity in men older than 65 with low testosterone levels.

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Transdermal testosterone treatment in men with low bioavailable testosterone levels does not impair and may improve cognitive function, but does not significantly improve health perception.

Testosterone administration to older men improves muscle function: molecular and physiological mechanisms.

Testosterone administration in older men leads to increased muscle protein anabolism and muscle strength, improving overall muscle function.

Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

High-dose testosterone supplementation stimulates daily GH production in older men, while low-dose testosterone supplementation has no significant effect on GH secretion in young men.

Citations

A Bibliometric Analysis of Testosterone Replacement Therapy Studies: Mapping the Scientific Landscape

Testosterone replacement therapy research has increasingly focused on hypogonadism, prostate cancer, and erectile dysfunction, advancing patient care in androgen deficiency management.

A study of long-term supraphysiologic-dose anabolic-androgenic steroid use on cognitive function in middle-aged men.

Long-term anabolic-androgenic steroid use in middle-aged men showed no significant cognitive impairments compared to age-matched non-users.

Age and objectively measured sleep: investigating associations and interactions by sex and race in middle-aged and older adults

Older age is associated with longer total sleep time from ages 40 to 70 and poorer sleep quality after age 40, with potential sex differences.

The different association between fat mass distribution and intake of three major nutrients in pre- and postmenopausal women

Dietary intake plays a crucial role in body fat distribution, with menopausal status significantly influencing the impact of nutrients on specific fat distribution metrics in women.

Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone

17-estradiol can prevent fat accumulation in adipocytes during early and late stages of maturation in females, while having a modest effect on male adipocytes.